Arthritis syndrome due to methimazole in 2 girls with hyperthyroidism
10.3760/cma.j.issn.1008﹣5734.2019.04.019
- VernacularTitle:甲巯咪唑致甲状腺功能亢进症患儿关节炎综合征2例
- Author:
Limin LIU
1
;
Hailiang LI
;
Lu PANG
;
Xu ZHU
;
Limei ZHAO
Author Information
1. 中国医科大学附属盛京医院药学部,沈阳,110004
- Publication Type:Journal Article
- Keywords:
Methimazole;
Arthritis
- From:
Adverse Drug Reactions Journal
2019;21(4):309-310
- CountryChina
- Language:Chinese
-
Abstract:
Two girls(patient 1,10 years old;patient 2,13 years old)received methimazole 10 mg orally twice daily for hyperthyroidism. They developed arthralgia on day 18 and day 20 after medication, respectively. The laboratory tests showed normal rheumatoid factor and negative anti﹣nuclear antibody. Arthritis syndrome caused by methimazole was considered. Methimazole was stopped in patient 1 immediately. The arthralgia disappeared 3 days after drug withdrawal,and then she was transferred to department of surgery for treatment of primary disease. Patient 2 received gradually reduced dose of methimazole(5 mg twice daily for 3 days,5 mg daily for 2 days)firstly,but the arthralgia did not improve. Then methimazole was stopped. Four days later,her arthralgia relieved. Patient 2 received methimazole 2. 5 mg every morning and 1. 25 mg every night again because of recurrence of hyperthyroidism. Four months after remedication, the arthralgia recurred. Methimazole was stopped again and replaced by propylthiouracil 18. 75 mg twice daily. Two weeks later,her arthralgia relieved and hyperthyroidism was well controlled. One month later, her arthralgia disappeared.
