Toxic epidermal necrolysis induced by mouse nerve growth factor for injection
10.3760/cma.j.issn.1008﹣5734.2019.04.020
- VernacularTitle:注射用鼠神经生长因子致中毒性表皮坏死松解症
- Author:
Daimei WANG
1
;
Ereyi ZHAO
;
Jingbo ZHONG
;
Fangxuan HAN
;
Xiuping LYU
Author Information
1. 海南省人民医院药学部,海口,570311
- Publication Type:Journal Article
- Keywords:
Nerve growth factors;
Epidermolysis bullosa;
Stevens﹣Johnson syndrome;
Drug eruptions;
Drug hypersensitivity
- From:
Adverse Drug Reactions Journal
2019;21(4):311-312
- CountryChina
- Language:Chinese
-
Abstract:
A 22﹣year﹣old female patient received methylprednisolone sodium succinate( methyl﹣prednisolone)for injection( 1 000 mg/d for 3 days and gradually reduced to 60 mg/d for maintenance therapy,IV infusion),immunoglobulin( 20 g/d,IV infusion),mouse nerve growth factor( 20 μg/d, intramuscular injection),vitamin B1(100 mg/d,intramuscular injection),and mecobalamin(1 mg/d,IV injection)for multiple sclerosis. Twelve days later,mouse nerve growth factor was temporarily discontinued and 7 days later,the drug was given again. On day 2 of retreatment,the patient developed conjunctival congestion. On day 3 of retreatment,red spots appeared on her chest,back,abdomen,and forearms. Then the rashes gradually increased,linked into pieces,and spread all over the body. Rashes partly formed blisters,blisters ulcerated,and epidermis exfoliated. It was considered that mouse nerve growth factor induced the toxic epidermal necrolysis. Then the drug was discontinued,the dose of methylprednisolone was increased to 500 mg/d,and at the same time,immunoglobulin,desloratadine,and fexofenadine were given. Twenty days later,the rashes subsided and pigmentation remained.
