Angioedema induced by ramipril
10.3760/cma.j.issn.1008﹣5734.2019.04.014
- VernacularTitle:雷米普利致血管性水肿
- Author:
Xu TIAN
1
;
Jiqiu HOU
;
Yanjiao LI
;
Hongmei ZHANG
Author Information
1. 吉林大学第一医院二部药学部,长春,130031
- Publication Type:Journal Article
- Keywords:
Ramipril;
Angioedema;
Angiotensin﹣converting enzyme inhibitors
- From:
Adverse Drug Reactions Journal
2019;21(4):299-300
- CountryChina
- Language:Chinese
-
Abstract:
A 62﹣year﹣old female patient received ramipril 2. 5 mg orally once daily for hypertension. About 12 hours after the first administration,the patient developed difficulty breathing,multiple skin rashes all over the body( mostly on chest and back,accompanied with itching),conjunctival hyperemia,lip swelling,oral mucosal hyperemia,pharyngeal congestion with pain,and etc. She was diagnosed with angioedema,which was considered to be caused by ramipril. Ramipril was stopped and anti﹣allergy treatments with adrenaline,promethazine hydrochloride,and dexamethasone were given. One hour later,the patient had improved symptoms and stable vital signs. On day 2 after the anti﹣allergy treatments,the patient had neither difficulty breathing nor new skin rash, and the anti﹣allergy drugs were replaced by methylprednisolone,calcium gluconate,and desloratadine cirate disodium. Antihypertensive treatment with levoamlodipine was also given. On day 3 after treatments,the patient′s skin rashes subsided with scars, congestion of the conjunctiva,oral mucosa,and pharynx relieved,and the lip swelling improved. On day 6 after treatments,the patient′s allergic symptoms completely disappeared,and her blood pressure was 122/78 mmHg.
