Anaphylactic shock and brain death induced by doxorubicin hydrochloride liposomes injection
10.3760/cma.j.issn.1008﹣5734.2019.04.015
- VernacularTitle:盐酸多柔比星脂质体注射液致过敏性休克并脑死亡
- Author:
Lichao MAO
1
;
Yue ZHANG
1
;
Huiyu YAN
1
;
Yueyang LI
1
Author Information
1. 吉林大学第一医院药学部,长春,130021
- Publication Type:Journal Article
- Keywords:
Doxorubicin;
Liposomes;
Anaphylaxis;
Shock;
Brain death
- From:
Adverse Drug Reactions Journal
2019;21(4):301-302
- CountryChina
- Language:Chinese
-
Abstract:
A 32﹣year﹣old woman received IV infusion of doxorubicin hydrochloride liposomes injection 20 mg,added into 5% glucose injection 250 ml,for malignant lymphoma. About 1 minute after the initiation of the IV infusion,the patient developed facial flushing and itchy throat. Two minutes later,the patient developed sudden convulsions, loss of consciousness, binocular gaze, trismus, and urinary incontinence. Anaphylactic shock was diagnosed and the drug was discontinued immediately. Treatments such as intravenous injections of adrenaline hydrochloride injection,dexamethasone sodium phosphate injection,and methylprednisolone sodium succinate for injection,oxygen inhalation,intravenous injections of nikethamide injection,lobeline hydrochloride injection,and norepinephrine bitartrate injection,and cardiopulmonary resuscitation were given successively. However,the patient had been in a deep coma without spontaneous breathing and her blood pressure and urination needed to be maintained by drugs. On day 112 of hospitalization,cerebrovascular color ultrasound showed spectrum changes of brain death. On day 253,the patient was discharged at the request of his family members.
