Research progress on near-infrared spectroscopic imaging in the diagnosis of depression
10.3760/cma.j.cn113661-20250103-00008
- VernacularTitle:功能性近红外光谱成像技术在抑郁症诊断中的研究进展
- Author:
Dan XIE
1
;
Jin CHEN
1
Author Information
1. 新疆心智发展与学习科学重点实验室 新疆师范大学心理学院，乌鲁木齐 830017
- Publication Type:Journal Article
- Keywords:
Spectroscopy, near-infrared;
Depressive disorder;
Diagnosis;
Hemoglobin concentration;
Integral/centroid values;
Functional connectivity
- From:
Chinese Journal of Psychiatry
2025;58(12):935-946
- CountryChina
- Language:Chinese
-
Abstract:
Functional near-infrared spectroscopy (fNIRS), with advantages such as portability, resistance to interference, and high ecological validity, has attracted growing attention in the study and diagnosis of depression. This review summarizes differences in three main fNIRS indicators-hemoglobin concentration, integral/centroid values, and functional connectivity-between patients with depression, healthy controls, and other psychiatric groups. Patients with depression show abnormal activation and reduced connectivity in key brain regions, especially the prefrontal and temporal cortices. More specifically, oxygenated hemoglobin levels in prefrontal regions decrease during cognitive tasks, while activation increases during emotion regulation tasks. Integral and centroid values show task-dependent changes, and functional connectivity is generally reduced. These indicators show potentiality in distinguishing depression from both healthy controls and patients with schizophrenia, bipolar disorder, and anxiety. Standardized paradigms, multimodal integration with AI, and large-scale longitudinal studies are needed to facilitate advance the clinical application translation of fNIRS in depression.
