Effects of various types of rodent Plasmodium parasites on the mouse immune response
10.3969/j.issn.1002-2694.2025.00.012
- VernacularTitle:不同类型啮齿类疟原虫对小鼠免疫应答反应的影响
- Author:
Xiao-feng LIANG
1
;
Yu-hong ZHANG
;
Yan-wei QI
Author Information
1. 广州医科大学生命科学学院,广州 511436
- Publication Type:Journal Article
- Keywords:
rodent malaria parasite;
immune cells;
immune cytokines;
malaria treatment
- From:
Chinese Journal of Zoonoses
2025;41(1):75-84
- CountryChina
- Language:Chinese
-
Abstract:
Malaria,an ancient disease caused by Plasmodium pathogens,poses a serious threat to human health.The body resists and suppresses Plasmodium invasion through two types of immune response:innate immunity and adaptive immunity.Innate immune cells and the cytokines that they produce constitute the first line of defense against foreign pathogens,whereas adaptive immunity has antimalarial effects primarily through humoral and cellular immunity.Rodent models of Plasmodium in-fection are suitable for studying the mechanism of malaria pathogenesis;therefore,exploring the effects of various rodent para-site types on the immune response in mice can advance understanding of malaria and provide research directions for the develop-ment of new treatment targets.This review summarizes various types of rodent Plasmodium parasites;immune cells and their cytokines acting during the immune response;and new targets for malaria treatment,in hopes of enhancing understanding of the immune response to malaria and exploring new directions in malaria treatment.
