Research progress on senescence-associated secretory phenotype in late-life depression
10.3760/cma.j.cn113661-20241031-00353
- VernacularTitle:老年期抑郁症中的衰老相关分泌表型研究进展
- Author:
Jianzhen HU
1
;
Yao GAO
1
;
Mixue ZHANG
1
;
Sha LIU
1
Author Information
1. 山西医科大学第一医院精神卫生科 精神障碍人工智能辅助诊疗山西省重点实验室，太原030001
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Late-life;
Senescence;
Senescence-associated secretory phenotype
- From:
Chinese Journal of Psychiatry
2025;58(6):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Late-life depression (LLD) is closely related to the aging process and is often accompanied by various somatic diseases, significantly affecting the quality of life in older adults. The senescence-associated secretory phenotype (SASP) refers to multiple factors released by senescent cells, including pro-inflammatory cytokines, chemokines, growth factors, and matrix metalloproteinases. In recent years, SASP has gained increasing attention due to its role in various physiological and pathological process by regulating the cellular microenvironment. This review summarizes the clinical research on SASP in LLD, explores its mechanisms of action and therapeutic potential, and aims to deepen the understanding of SASP in the pathogenesis of LLD and provide new insights for diagnosing and treating LLD.
