Liver injury induced by yuanhu Zhitong dropping pills(元胡止痛滴丸)
10.3760/cma.j.issn.1008﹣5734.2019.04.011
- VernacularTitle:元胡止痛滴丸致肝损伤
- Author:
Yanyan ZHAO
1
;
Lingling NIU
;
Yuanyuan LI
Author Information
1. 济宁医学院附属医院药剂科,山东省济宁市,272029
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Yuanhu Zhitong dropping pills
- From:
Adverse Drug Reactions Journal
2019;21(4):293-294
- CountryChina
- Language:Chinese
-
Abstract:
A 54﹣year﹣old female patient received Yuanhu Zhitong dropping pills 30 pills thrice daily for pelvic inflammatory﹣related abdominal pain. Six months after medication,the patient developed anorexia, nausea,dark brown urine,and skin pruritus. After taking Hugan tablets(护肝片)orally for 2 weeks,the symptoms did not improve. The patient stopped using Yuanhu Zhitong dropping pills by himself. On day 7 of drug withdrawal, the laboratory tests showed alanine aminotransferase( ALT ) 679 U/L, aspartate aminotransferase(AST)698 U/L,total bilirubin(TBil)66. 5 μmol/L,and direct bilirubin(DBil)51. 8 μmol/L. Liver injury induced by Yuanhu Zhitong dropping pills was considered. Hepatoprotection treatments were given. Seven days later,the laboratory tests showed ALT 278 U/L,AST 317 U/L,TBil 150. 8 μmol/L,and DBil 115. 4 μmol/L. Twenty﹣five days later,the patient did not complain of discomfort,above symptoms disappeared,and the laboratory tests showed ALT 54 U/L,AST 49 U/L,TBil 44. 5 μmol/L,and DBil 39. 0 μmol/L. At 4 months of follow﹣up,the patient had normal liver function.
