Lower extremity thrombophlebitis caused by propofol injection
10.3760/cma.j.issn.1008﹣5734.2019.04.012
- VernacularTitle:丙泊酚注射液致下肢血栓性静脉炎
- Author:
Xin ZHANG
1
;
Shengbo FANG
;
Na ZHOU
Author Information
1. 吉林大学第一医院药学部,长春,130021
- Publication Type:Journal Article
- Keywords:
Propofol;
Phlebitis;
Thrombophlebitis;
Anesthesia
- From:
Adverse Drug Reactions Journal
2019;21(4):295-296
- CountryChina
- Language:Chinese
-
Abstract:
A 27﹣year﹣old male patient underwent left maxillary masses excision for periapical cysts in the left maxillary under general anesthesia. During the surgery,a venous access was established from the peripheral vein of the patient′s left lower extremity,and anesthetic drugs(propofol injection,succinylcholine chloride injection,remifentanil hydrochloride for injection,dexmedetomidine hydrochloride injection)were given. On day 2 after surgery,the patient developed topical redness and swelling along the blood vessel on his left lower extremity,which gradually developed into a cord﹣like redness and swelling,with increased blood vessel stiffness. He was diagnosed with thrombophlebitis of the left great saphenous vein after a ultrasound examination of the blood vessel. Treatments such as subcutaneous injection of enoxaparin sodium, oral administration of extract of horse chestnut seeds, topical mucopolysaccharide polysulfate cream, physiotherapy,and etc. were given. On day 10 after surgery,the redness and swelling on the patient′s left lower extremity disappeared,and the blood vessel was softened. At 2 months of follow﹣up,ultrasound examination revealed partial recanalization of the left venous trunk( the calf part ) of saphenous vein. According to the drug labels and literature reports,it was considered that the patient′s thrombophlebitis might be associated with propofol injection.
