Anaphylactic shock caused by compound glycyrrhizin for injection
10.3760/cma.j.issn.1008﹣5734.2019.04.013
- VernacularTitle:注射用复方甘草酸苷致过敏性休克
- Author:
Xinlu WANG
1
;
Yueyang LI
1
;
Huiyu YAN
1
;
Xiangfeng WANG
1
Author Information
1. 吉林大学第一医院药学部,长春,130021
- Publication Type:Journal Article
- Keywords:
Anaphylaxis;
Shock;
Compound glycyrrhizin
- From:
Adverse Drug Reactions Journal
2019;21(4):297-298
- CountryChina
- Language:Chinese
-
Abstract:
A 43﹣year﹣old female patient was given IV infusions of reduced glutathione for injection (1. 2 g,added in 100 ml of 5% glucose injection),polyenephosphatidylcholine( 697. 5 mg,added in 250 ml of 5% glucose injection),and compound glycyrrhizin for injection(120 mg,added in 250 ml of 5% glucose injection)once daily for liver injury. After 20 minutes of the first infusion of compound glycyrrhizin for injection( the injection volume was about 50 ml ),the patient developed skin rash,palpitations, dyspnea,drenching sweats,abdominal pain,and dysphoria. Meanwhile her heart rate was 126 beats/min and blood pressure was 85/45 mmHg. In consideration of anaphylactic shock caused by compound glycyrrhizin,the drug was immediately stopped and IV injections of dexamethasone, promethazine hydrochloride,and calcium gluconate were given. Then the patient′s symptoms relieved. Except for polyenephosphatidylcholine,the compound glycyrrhizin for injection and reduced glutathione for injection were discontinued the next day and IV infusion of acetylcysteine(8 g,added in 250 ml of 10% glucose injection)once daily and oral bicyclol tablets 50 mg thrice daily were given. The patient did not developed anaphylaxis again. Seven days later,the patient′s fatigue induced by liver injury obviously improved.
