Advances in neuroimaging of suicidality in adolescents with major depressive disorder
10.3760/cma.j.cn113661-20241112-00378
- VernacularTitle:青少年抑郁症患者自杀相关的神经影像学研究进展
- Author:
Yiwei HU
1
;
Dandan FAN
;
Chunming XIE
Author Information
1. 东南大学医学院，南京210009
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Adolescent;
Magnetic resonance imaging;
Suicidal ideation;
Suicidal behavior
- From:
Chinese Journal of Psychiatry
2025;58(5):377-383
- CountryChina
- Language:Chinese
-
Abstract:
The prevalence of suicidal ideation (SI) and suicide behavior (SB) has gradually risen among adolescents with major depressive disorders in recent years, yet the underlying neurological mechanisms remain unknown. With the advancement of neuroimaging technology, multimodal magnetic resonance imaging (MRI) methods show fundamental value in detecting structural and functional brain abnormalities associated with these conditions. Preliminary studies have revealed alterations in key brain regions, such as the prefrontal cortex, amygdala, and anterior cingulate cortex, in adolescents with major depressive disorders. These findings provide critical insights into the neuropathological basis and underlying mechanisms of SI and SB in adolescent major depressive disorders. This review summarizes recent advances in brain structure and function in adolescents with major depressive disorder who exhibit SI and/or SB using diverse MRI techniques. This paper will provide new insights for the investigation of the neurobiological mechanisms underlying suicidality in adolescents with major depressive disorder, and provide objective neuroimaging evidence for the early identification and individualized intervention for at-risk adolescents.
