Advances in Mendelian randomization analysis of depressive disorder, selected physical diseases and physical characteristics
10.3760/cma.j.cn113661-20241107-00369
- VernacularTitle:抑郁症与躯体疾病及躯体特征的孟德尔随机化分析研究进展
- Author:
Yu CHEN
1
;
Yang GUO
1
;
Yan JIANG
1
;
Yihan YAO
1
;
Yonggui YUAN
1
;
Zhi XU
1
Author Information
1. 东南大学附属中大医院心身医学科 江苏省脑科学与脑医学重点实验室，南京 210009
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Physical disease;
Exercise;
Sleep disorders;
Body mass index;
Carbohydrates;
Mendelian randomization;
Causality
- From:
Chinese Journal of Psychiatry
2025;58(7):571-578
- CountryChina
- Language:Chinese
-
Abstract:
Depressive disorder is a psychiatric disorder primarily characterized by low emotions. Clinical observational studies indicate relationships between depressive disorder and certain physical diseases or characteristics, though the causality of these relationships remains unclear. Mendelian Randomization has gradually become an important tool to explore potential causal relationships between diseases, leveraging the advantages of genetic data analysis. It has been used to examine the relationship between depressive disorder and other diseases. This review summarizes the findings of causal relationships between depressive disorder and diseases affecting the cardiovascular, neurological, digestive, endocrine, and female reproductive systems, as well as some physical characteristics, including physical activity level, insomnia, circadian rhythm preferences, obesity, and carbohydrate intake. The review also introduces the principle of Mendelian Randomization and discusses its future applications.
