Effect of Siwu Decoction in the prevention and treatment of liver diseases and its mechanism
- VernacularTitle:四物汤对肝脏疾病的防治效应及其机制
- Author:
Yajie GUAN
1
;
Lihui ZHANG
;
Sutong LIU
;
Qizhen ZHANG
;
Wenxia ZHAO
;
Minghao LIU
Author Information
- Publication Type:Journal Article
- Keywords: Liver Diseases; Si Wu Decoction; Pharmacology(TCD)
- From: Journal of Clinical Hepatology 2025;41(7):1450-1455
- CountryChina
- Language:Chinese
- Abstract: Siwu Decoction is a classic formula for tonifying the blood and activating blood circulation and is characterized by its ability to tonify the blood without leaving stasis and promote blood circulation without harming the vital energy of the body.It is widely used in clinical practice for the treatment of various conditions related to blood deficiency and poor blood circulation,such as anemia,menstrual disorders,and dysmenorrhea.The liver is responsible for governing the free flow of Qi and storing blood,and abnormalities in liver function are associated with various acute and chronic liver injuries.Siwu Decoction can restore liver homeostasis by tonifying the blood,activating blood circulation,nourishing the blood,and soothing the liver.Based on its unique prescription formulation and multiple pharmacological mechanisms,Siwu Decoction has become an important prescription for enhancing liver microcirculation,facilitating hepatocyte repair and regeneration,and alleviating liver injury.This article reviews the effect and mechanism of Siwu Decoction in the prevention and treatment of various liver injuries(including alcoholic liver disease,nonalcoholic fatty liver disease,nonalcoholic fatty liver disease,liver fibrosis,and liver cirrhosis)and discusses existing problems and future research directions.
