Association between bile acid/short-chain fatty acid metabolic disorders and hepatic encephalopathy based on the traditional Chinese medicine theory of Yin and Yang
10.12449/JCH250733
- VernacularTitle:基于中医阴阳学说探讨胆汁酸/短链脂肪酸代谢紊乱与肝性脑病的关系
- Author:
Luyi YAN
1
;
Weiyu CHEN
;
Han WANG
;
Wenqian FENG
;
Yang DU
;
Xueru TIAN
;
Yang HONG
;
Dewen MAO
;
Lei FU
;
Chun YAO
Author Information
1. 广西中医药大学研究生院,南宁 530200
- Publication Type:Journal Article
- Keywords:
Hepatic Encephalopathy;
Yin Yang Theory;
Bile Acid;
Fatty Acids
- From:
Journal of Clinical Hepatology
2025;41(7):1443-1449
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic encephalopathy is a neuropsychiatric syndrome secondary to severe liver disease.Recent studies have shown that the development of hepatic encephalopathy is closely associated with bile acid/short-chain fatty acid metabolic disorder.As the core theory of traditional Chinese medicine,the theory of Yin and Yang provides a unique perspective for analyzing the association between bile acids/short-chain fatty acids and hepatic encephalopathy.Bile acids function like Yang,governing the free flow of Qi and assisting in metabolic processes,while short-chain fatty acids belong to Yin,maintaining internal stability and conservation,preserving the intestinal barrier,and combating inflammation and toxins.Bile acids and short-chain fatty acids constrain each other and are interdependent to regulate the dynamic equilibrium of the gut-liver-brain axis.On this basis,by regulating the metabolic imbalance of bile acids and short-chain fatty acids,it is expected to restore the dynamic balance of Yin and Yang in patients with hepatic encephalopathy under the synergistic intervention of traditional Chinese medicine and Western medicine.
