Association between liver radiodensity and the degree of liver fibrosis in patients with chronic hepatitis B
10.12449/JCH250720
- VernacularTitle:肝脏放射密度与慢性乙型肝炎肝纤维化程度的关联性分析
- Author:
Zheyu LI
1
;
Lili WANG
;
Xiaoyue ZHANG
;
Cuifang HE
;
Min LI
;
Shan WANG
;
Xiaoqin GAO
;
Longzhen SHI
;
Jianjun JIN
;
Liting ZHANG
;
Junfeng LI
Author Information
1. 兰州大学第一临床医学院,兰州 730000
- Publication Type:Journal Article
- Keywords:
Hepatitis B,Chronic;
Hepatic Fibrosis;
Liver Radiodensity
- From:
Journal of Clinical Hepatology
2025;41(7):1358-1363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of liver radiodensity with the degree and progression of liver fibrosis in patients with chronic hepatitis B(CHB).Methods A retrospective cohort study was conducted among 114 CHB patients who were hospitalized in The First Hospital of Lanzhou University from January to December 2019,and related clinical data were collected,including laboratory tests and abdominal CT.The metabolic characteristics of the patients were assessed,and liver radiodensity was measured.An analysis of variance was used for comparison of normally distributed continuous data between three groups,and the Kruskal-Wallis H rank sum test was used for comparison of continuous data with skewed distribution between three groups;the chi-square test or the Fisher's exact test was used for comparison of categorical data between three groups.A logistic regression analysis was used to investigate the influencing factors for the degree of liver fibrosis,and the Cox proportional-hazards regression model analysis was used to investigate the influencing factors for the progression of liver fibrosis in CHB.Results Among the 114 patients enrolled,43(37.72％)had no liver cirrhosis,30(26.32％)were suspected of liver cirrhosis,and 41(35.96％)had liver cirrhosis,with a median follow-up time of 538.5(322.75-1 031.50)days.Liver radiodensity on plain scan(odds ratio[OR]=0.81,95％confidence interval[CI]:0.68-0.97,P=0.025),liver radiodensity on contrast-enhanced scan(OR=0.95,95％CI:0.90-0.99,P=0.037),and liver volume(OR=0.99,95％CI:0.98-0.99,P<0.001)were independent influencing factors for the degree of liver fibrosis.The univariate Cox regression analysis showed that the low level of HDL(hazard ratio=2.81,95％CI:1.04-7.54,P=0.041)was associated with the progression of liver fibrosis in CHB patients,and the degree of liver fibrosis,liver volume,and liver radiodensity showed no significant association with the progression of liver fibrosis(all P>0.05).Conclusion In CHB patients,liver radiodensity is an independent influencing factor for the degree of liver fibrosis,and low HDL has a marked influence on the progression of liver fibrosis.
