Correlation analysis between hair fluorine level and hypertension of permanent residents in high altitude areas of Tibet Autonomous Region
10.3760/cma.j.cn231583-20240429-00114
- VernacularTitle:西藏自治区高海拔地区常住居民头发氟含量与高血压的相关性分析
- Author:
Xingmin LIU
1
;
Lijun LIU
1
;
Zhiying ZHANG
1
;
Jing WANG
1
;
Siwei FENG
1
;
Haoshuang ZHAN
1
;
Lifeng MA
1
;
Longli KANG
1
Author Information
1. 西藏民族大学医学部 高原病分子遗传机制与干预研究省级重点实验室 高原环境与疾病相关基因研究高校重点实验室，咸阳 712000
- Publication Type:Journal Article
- Keywords:
Fluorine;
Blood pressure;
High altitude
- From:
Chinese Journal of Endemiology
2025;44(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation between hair fluorine level and hypertension of permanent residents in high altitude areas of Tibet Autonomous Region (Tibet).Methods:A random cluster sampling method was used to select 5 villages in the high altitude areas of Tibet from June to August 2021 and June to August 2022, respectively, and questionnaire survey, physical examination, and biochemical indicator testing were conducted on permanent Tibetan residents in the above mentioned villages. At the same time, hair samples were collected, the hair fluorine level was determined by ion selective electrode method, and the correlation between various indicators and hair fluorine level and hypertension was analyzed.Results:A total of 227 individuals were included, with hair fluorine level of (15.06 ± 0.16) mg/kg. Correlation analysis showed that there was no correlation between the study subjects' systolic blood pressure, diastolic blood pressure, body mass index, pulse, neck circumference, chest circumference, uric acid level and hair fluorine level ( P > 0.05). Abdominal circumference, hip circumference, and hemoglobin level were positively correlated with hair fluorine level ( r = 0.23, 0.14, 0.29, P < 0.05), while blood glucose level and finger pulse oxygen were negatively correlated with hair fluorine level ( r = - 0.23, - 0.24, P < 0.001). Binary logistic regression analysis showed that age ( OR = 1.04, 95% CI: 1.01 - 1.06), chest circumference ( OR = 1.10, 95% CI: 1.01 - 1.20), and hair fluorine level ( OR = 1.22, 95% CI: 1.02 - 1.46) had an impact on hypertension ( P < 0.05). Conclusion:There is a certain correlation between hair fluoride level and hypertension in the population of high altitude areas in Tibet.
