Research Progress on Fibroblast Activation Protein Inhibitor-Positron Emission Tomography in the Diagnosis and Treatment of Interstitial Lung Disease
10.12376/j.issn.2097-0501.2025.02.014
- VernacularTitle:成纤维细胞激活蛋白抑制剂-正电子发射计算机断层显像在间质性肺疾病诊疗中的研究进展
- Author:
Zhiyi LI
1
;
Ruxuan CHEN
1
;
Chi SHAO
1
;
Hui HUANG
1
Author Information
1. 中国医学科学院北京协和医院呼吸与危重症医学科,北京 100730
- Publication Type:Journal Article
- Keywords:
fibroblast activation protein;
chest imaging;
positron emission tomography;
interstitial lung disease
- From:
JOURNAL OF RARE DISEASES
2025;4(2):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Chest imaging examination plays an important role in the diagnosis,evaluation and prognosis of interstitial lung disease(ILD).However,the widely used chest high-resolution computed tomography(CT)can only reveal the extent and morphological characteristics of pulmonary lesions,but it can not reflect the pathophysiological process(inflammation or fibrosis)of pulmonary lesions.Recent studies showed that fibroblast activation protein(FAP)can be relatively specifically expressed in fibroblasts activated in fibrotic ar-eas,and FAP inhibitor positron emission tomography(FAPI-PET)may reflect the degree of pulmonary fibrosis and the activity of fibroblasts,which has been used to evaluate the degree of fibrosis in various ILD.In this pa-per,the role and expression of FAP in pulmonary fibrosis and inflammatory tissue of ILD are reviewed,and the recent application of FAPI-PET in various ILD is summarized,which provides insight for the development of new imaging methods for the diagnosis and assessment of ILD.
