Clinical and epidemic characteristics of 27 cases of brucellosis in Hainan
10.3760/cma.j.cn231583-20240325-00070
- VernacularTitle:海南地区27例布鲁氏菌病病例临床及流行特征分析
- Author:
Qi WANG
1
;
Yuyan WANG
;
Yuanze CHEN
;
Xiaojing ZHENG
;
Dongyao CAI
;
Feifei YIN
;
Yongguo DU
;
Liyuan ZHANG
Author Information
1. 海南医科大学第二附属医院感染病与热带病科，海口 570311
- Publication Type:Journal Article
- Keywords:
Brucellosis;
Epidemiology;
Clinical features
- From:
Chinese Journal of Endemiology
2024;43(12):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical, epidemic and laboratory characteristics of brucellosis in Hainan, and to summarize the experience of diagnosis and treatment.Methods:The epidemiological characteristics, clinical manifestations, laboratory results, treatment and prognosis of 27 inpatients with brucellosis admitted to the Second Affiliated Hospital of Hainan Medical University from January 2019 to December 2023 were retrospectively analyzed.Results:In 27 cases, the male to female ratio was 2.38 ∶ 1.00 (19 ∶ 8). Occupational distribution was dominated by farmers and herdsmen, with a total of 21 cases (77.8%). Twenty-one patients (77.8%) had a clear history of contact with cattle, sheep, and related products, and there was a phenomenon of family clustering. Eighteen patients (66.7%) developed symptoms from March to July. The clinical manifestations of the patients were lack of specificity, mainly fever (24 cases, 88.9%), dizziness and headache (13 cases, 48.1%), and low back pain (11 cases, 40.7%). Some patients also had symptoms and signs such as fatigue (8 cases), muscle pain (6 cases), chest tightness (4 cases), and splenomegaly (6 cases). Complications commonly included pulmonary infection (13 cases, 48.1%) and spinal involvement (11 cases, 40.7%). The positive rates of Brucella blood culture, tube agglutination test, Rose Bengal plate agglutination test, and cerebrospinal fluid or joint cavity effusion culture were 76.9% (20/26), 100.0% (21/21), 100.0% (11/11), and 3/4, respectively. The combination therapy of doxycycline and rifampicin showed good therapeutic effects, and 22 patients were cured. Conclusions:Hainan is not an epidemic area of brucellosis, and the clinical manifestations of the disease are not specific. The epidemic and clinical characteristics of the disease should be paid attention to in order to improve the level of diagnosis and treatment and control effectiveness.
