Research progress on the neuroimaging mechanism of anhedonia in major depressive disorder
10.3760/cma.j.cn113661-20240206-00058
- VernacularTitle:抑郁症快感缺失的神经影像学机制研究进展
- Author:
Shijie LUO
1
;
Yiliang ZHANG
1
;
Shuming ZHONG
1
;
Shunkai LAI
1
;
Yanbin JIA
1
Author Information
1. 暨南大学附属第一医院精神医学科，广州 510630
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Anhedonia;
Reward circuit;
Inflammation;
Metabolic disorde
- From:
Chinese Journal of Psychiatry
2025;58(2):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Anhedonia is one of the core symptoms of major depressive disorder, and its underlying mechanisms remain unclear. The regulation of the reward process in brain regions, such as the hippocampus, amygdala, striatum, ventral tegmental brain, and prefrontal lobe, may play a role in anhedonia. This study has concluded the changes in relevant brain regions in reward anticipation, decision-making, and feedback processes. The neuroimaging mechanisms of inflammation, neurotransmitter metabolism, and gene expression on depression anhedonia symptoms were reviewed.
