Correlation analysis of adiponectin, platelet to lymphocyte ratio and interleukin-6 with the disease activity of Sj?gren syndrome
10.3760/cma.j.cn115455-20231123-00497
- VernacularTitle:脂联素、血小板与淋巴细胞比值和白细胞介素6水平与干燥综合征患者疾病活动度的相关性分析
- Author:
Meng CHEN
1
;
Xiaojie LI
1
Author Information
1. 山东省立医院菏泽医院风湿免疫科，菏泽 274000
- Publication Type:Journal Article
- Keywords:
Sj?gren syndrome;
Adiponectin;
Platelet to lymphocyte ratio;
Interleukin-6
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(2):186-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of adiponectin, platelet to lymphocyte ratio (PLR), and interleukin-6 (IL-6) with the disease activity of Sj?gren syndrome(SS).Methods:A total of 100 patients with SS who were treated in the Shandong Provincial Hospital Heze Hospital from January 2020 to December 2022 were selected as the research group. According to the disease activity index formulated by the European League of Rheumatic Diseases(ESSDAI), they were divided into two groups, 50 cases in the active group and 50 cases in the non-active group. Meanwhile, 40 healthy subjects were selected as the control group. The differences of APN, PLR, and IL-6 among the groups were compared. The correlationof PLR, APN, IL-6 and immunoglobulin(Ig)G, IgA, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP) and disease activity in SS patients were analyzed by Pearson test.Results:The levels of APN, PLR and IL-6 in the research group were higher than those in the control group: (10.77 ± 7.63) mg/L vs. (2.44 ± 1.27) mg/L, (193.67 ± 50.53)% vs. (113.74 ± 46.25)%, (0.97 ± 0.20) ng/L vs. (0.49 ± 0.09) ng/L, there were statistical differences ( P<0.05). The levels of APN, PLR, IL-6, ESR, CRP, IgA and IgG in the active group were higher than those in the non-active group: (13.37 ± 11.60) mg/L vs. (8.31 ± 6.92) mg/L, (193.35 ± 50.60)% vs. (132.07 ± 38.36)%, (128.20 ± 13.10) ng/L vs. (93.20 ± 12.57) ng/L, (37.52 ± 7.03) mm/1 h vs. (28.44 ± 5.80) mm/1 h, (9.10 ± 2.53) mg/L vs. (4.77 ± 1.45) mg/L, (22.98 ± 4.83) g/L vs. (12.80 ± 3.72) g/L, (3.51 ± 1.03) g/L vs. (1.94 ± 0.50) g/L, there were statistical differences ( P<0.05). The results of the Pearson test showed that APN had no correlation with ESR and CRP ( r = 0.176, 0.032, P>0.05), but had positively correlated with IgA and IgG ( r = 0.251, 0.024, P<0.05). PLR had positively correlated with ESR, CRP, IgA and IgG ( r = 0.370, 0.343, 0.449, 0.379, P<0.05). APN, PLR, and IL-6 had positively correlated with disease activity in patients with SS( r = 0.098, 0.603, 0.810, P<0.05). Conclusions:The APN, PLR and IL-6 may participate in the occurrence and development of SS disease. APN and PLR have a correlation with ESR, CRP, IgA and IgG to some extent. APN, PLR, and IL-6 can be used as effective indicators to reflect the condition and activity of SS patients.
