The key research progress and hot spots of major depressive disorder over the past decade
10.3760/cma.j.cn113661-20241103-00360
- VernacularTitle:抑郁症近10年研究进展及热点问题
- Author:
Gang WANG
1
;
Shanshan TIAN
1
;
Ling ZHANG
1
;
Anning LI
1
Author Information
1. 首都医科大学附属北京安定医院，北京100088
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Epidemiology;
Pathogenesis;
Clinical therapeutics
- From:
Chinese Journal of Psychiatry
2025;58(2):94-102
- CountryChina
- Language:Chinese
-
Abstract:
Over the past decade, the research on major depressive disorder (MDD) has made steady progress globally. The prevalence of MDD is high with a noticeable trend toward younger and professional. Additionally, MDD is grappling with heavy burdens. Genome-wide association studies have shed light on the heritability of MDD, while imaging studies have identified diverse biological subtypes. Furthermore, multi-omics studies have uncovered potential biomarkers for the condition. The emergence of novel therapeutic agents and advancements in brain stimulation techniques have introduced innovative strategies for the management of MDD. Digital therapeutics are rapidly advancing, holding the promise of delivering personalized and full-course care for MDD patients. This article provides a comprehensive overview of the key research progress and hot spots in the epidemiology, etiology, and clinical therapeutics of MDD over the past decade. It aims to assist clinicians in understanding the current state of research and the future directions within this domain.
