The survival benefit of plasma exchange in patients with acute liver failure:Controversies and thoughts
- VernacularTitle:急性肝衰竭血浆置换治疗生存获益的争议与思考
- Author:
Di YANG
1
;
Qinglong JIN
1
Author Information
- Publication Type:Journal Article
- Keywords: Liver Failure,Acute; Plasma Exchange; Multiple Organ Failure; Liver Transplantation
- From: Journal of Clinical Hepatology 2025;41(7):1275-1278
- CountryChina
- Language:Chinese
- Abstract: Acute liver failure(ALF)is a rare but life-threatening clinical syndrome,and supportive care and liver transplantation are currently the main treatment methods for ALF.Plasma exchange(PEX),as a blood purification technique,can remove inflammatory mediators and toxins,and it is a widely used alternative therapy for liver transplantation in clinical practice.Studies have shown that PEX can alleviate inflammatory response,stabilize hemodynamics,and improve survival rate in ALF patients.However,a multicenter retrospective cohort study in the UK published in Journal of Hepatology in April 2025 showed that there was no improvement in overall survival benefit or transplantation-free survival rate in ALF patients after PEX,which has led to widespread debate in the academic world.This article reviews the advances in the application of PEX in ALF and discusses related controversial issues.
