Advances in basic research on transient receptor potential vanilloid 1 channel in the pathogenesis and treatment of major depressive disorder
10.3760/cma.j.cn113661-20240714-00237
- VernacularTitle:瞬时受体电位香草酸亚型1通道在抑郁症发病机制和治疗中的基础研究进展
- Author:
Junjie HUANG
1
;
Yinping XIE
;
Hailong GE
;
Chen LI
;
Lujia SI
;
Lan WU
;
Ling XIAO
;
Gaohua WANG
Author Information
1. 武汉大学人民医院精神科，武汉 430060
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Synaptic transmission;
Neurogenesis;
Transient receptor potential vanilloid 1 channel;
Neuroinflammation
- From:
Chinese Journal of Psychiatry
2025;58(1):69-74
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder (MDD) is a common mental disorder characterized by long-term low mood, anhedonia, and may even lead to suicidal behavior. The development and progression of MDD involves a range of pathological alterations in the central nervous system, including dysfunction of synaptic transmission, hyper-activation of neuroinflammation, and diminished neurogenesis. The transient receptor potential vanilloid 1 (TRPV1) channel is highly expressed in brain regions associated with depression, and can regulate physiological activities such as neuroinflammation, neurogenesis, and synaptic transmission efficacy. Hence, the TRPV1 channel should be implicated in the pathogenesis of depression and be considered as a promising candidate for antidepressant treatment. This paper provides an overview of the structure and function of TRPV1 channel, with a focus on elucidating the potential mechanism of action of TRPV1 channel in depression, and explores its research trajectory and development prospects in the context of depression therapy.
