Etiological characteristics of Salmonella enterica serovar Goldcoast isolates from Yangzhou,according to whole-genome sequencing
10.3969/j.issn.1002-2694.2025.00.104
- VernacularTitle:基于全基因组测序技术分析扬州市黄金海岸沙门氏菌病原学特征
- Author:
Ya-wen XU
1
;
Yan WANG
1
;
Rong-rong XU
1
;
Rong-rong LU
1
;
Hang-ning YING
1
;
Le ZHOU
1
Author Information
1. 扬州市疾病预防控制中心,扬州 225009
- Publication Type:Journal Article
- Keywords:
Salmonella enterica serovar Goldcoast;
multidrug resistance;
Whole Genome Sequencing;
CRISPR typing;
single nucleotide polymorphism
- From:
Chinese Journal of Zoonoses
2025;41(6):597-602
- CountryChina
- Language:Chinese
-
Abstract:
Salmonella enterica serovar Goldcoast isolates from Yangzhou were analyzed for assessment of their pathogenic and ge-nomic characteristics.From 2017 to 2023,eight strains were detected through foodborne disease surveillance and health check-ups.These strains exhibited resistance to two to seven antibiotic classes,and all strains bore a T57S mutation in the parC gene.Notably,50％(4/8)of the strains carried sulfonamide resistance genes(sul1 or sul3),and 37.5％(3/8)were positive for extended-spectrum beta-lactamase(ESBL)genes,including blaCTX-M-55 and blaTEM-1.Multilocus sequence typing(MLST)revealed that ST358(five strains)and ST2529(three strains)were the predominant sequence types,corresponding to CRISPR Ⅰ and Ⅱ groups,respectively.Single nucleotide polymorphism(SNP)phylogenetic analysis indicated a close genetic relationship between the case isolate Sal-2214 and strains from multiple regions,with a SNP difference≤20,thus suggesting potential inter-regional transmission.For example,one isolate from the stool of a 4-year-old child with diarrhea(Sal-2214)carried the beta-lactam resistance gene(blaCTX-M-55)and exhib-ited high resistance to cefotaxime(CTX)and ceftazidime(CAZ).These findings indicated that S.enterica Goldcoast emerged in Yang-zhou from 2022,and was characterized by multidrug resistance and a genetic relationship with strains from coastal regions.These find-ings highlight the need for enhanced resistance monitoring and trace-back studies to better understand the epidemiology and control the potential spread of this pathogen.
