Two cases of female monozygotic twins with schizophrenia carrying a balanced translocation between 22q11.2 and 4p15.3
10.3760/cma.j.cn113661-20240830-00290
- VernacularTitle:女性同卵双胞胎精神分裂症携带22q11.2和4p15.3平衡易位2例
- Author:
Xuyuan YIN
1
;
Chuanwei LI
;
Qing YANG
;
Yuan CAI
;
Wenlong HOU
;
Lijuan MAN
;
Nannan ZHUANG
;
Jiaqi CAO
;
Qi QI
;
Zhenhua ZHU
;
Li HUI
Author Information
1. 苏州大学附属广济医院生物精神医学研究中心，苏州 215137
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Monozygotic twins;
Chromosome aberrations;
Balanced translocation
- From:
Chinese Journal of Psychiatry
2025;58(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is a common, severe, and complex psychiatric disorder worldwide. Genetic factors account for around 80% of the etiology of schizophrenia, yet objective diagnostic biomarkers remain lacking. This article reports two cases of female monozygotic twins diagnosed with schizophrenia, exhibiting a balanced translocation between 22q11.2 and 4p15.3. Reviewing the literature, we analyze and discuss the correlation between chromosomal balanced translocation regions and the pathogenesis of mental disorders. This aims to encourage psychiatrists to consider new perspectives on the diagnosis of schizophrenia.
