Drug resistance,serotypes,and molecular characteristics of Vibrio parahaemolyticus in Suzhou
10.3969/j.issn.1002-2694.2025.00.100
- VernacularTitle:苏州市副溶血性弧菌耐药、血清型及分子特征分析
- Author:
Xiao-long WANG
1
;
Wen-yan ZOU
1
;
Li-qin ZHU
1
;
Meng-han ZHANG
1
Author Information
1. 苏州市疾病预防控制中心,苏州 215137;苏州市新发突发重大传染病病原微生物重点实验室,苏州 215137
- Publication Type:Journal Article
- Keywords:
Vibrio parahaemolyticus;
whole genome sequencing;
drug resistance;
serotypes;
molecular characteristics
- From:
Chinese Journal of Zoonoses
2025;41(6):574-582
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed at studying the drug resistance,serotypes,and molecular characteristics of Vibrio parahaemo-lyticus(VP)in Suzhou,to provide basic data for the prevention and control of VP-related diseases.Drug susceptibility testing of 177 VP strains isolated from Suzhou City in 2023 was performed with the microbroth dilution method.Virulence genes,serotypes,and multi-locus sequence typing(MLST)were analyzed on the basis of whole genome sequencing results.The drug resistance rate of 177 VP strains was highest against cefazolin(100.00%),followed by ampicillin(77.97%),and polymyxine E(63.84%),and the multiple drug resistance rate was 53.67%.In clinical isolates,O10∶K4(37.41%)was the most abundant serotype,and was followed by O3∶K6(28.78%),and ST3 was the dominant ST type.The main virulence genes of clinical isolates were tlh+,tdh+,and trh-(79.86%),whereas the virulence genes in food isolates were all tlh+,tdh-,and trh-.Strains of the same serotype clustered together in the SNP phylogenetic tree.The environmental isolates showed no obvious dominant serotype or ST type.In Suzhou,VP has a high proportion of multi-drug resistance,the clinical isolates have prevalent serotypes and ST types,and most isolates carried virulence genes;there-fore,monitoring should be strengthened.
