Characteristics of listeriosis cases reported in the literature in China,2010-2023
10.3969/j.issn.1002-2694.2025.00.095
- VernacularTitle:2010-2023年中国文献报告李斯特菌病病例流行特征分析
- Author:
Zhi-fang ZHANG
1
;
Xue-Jie LIU
1
;
Wei-wei CHEN
1
;
Yan-qin DENG
1
Author Information
1. 福建省疾病预防控制中心/福建省人兽共患病重点实验室,福州 350012
- Publication Type:Journal Article
- Keywords:
Listeria monocytogenes;
listeriosis;
mortality rate;
foodborne disease;
meningitis;
sepsis
- From:
Chinese Journal of Zoonoses
2025;41(6):653-659
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzed the demographic characteristics and clinically significant inflammatory index changes in listeriosis cases in China from 2010 to 2023.The aim was to understand Listeria monocytogenes susceptibility,to provide a reference for listeriosis prevention and control.Records in three Chinese databases—the China Knowledge Network,Wanfang Database,and VIP Database—from January 1,2010,to December 31,2023,were searched.Statistical analysis was conducted on the clinical features and epidemiological information for all identified cases.A total of 693 cases of listeriosis were included:482 occurring during the perinatal period and 211 occurring outside the perinatal period.The average mortality rate was 17.2%(119/693).The predominant clinical manifestations of listeriosis in neonatal patients during the perinatal period were sepsis(75.5%,241/319)and meningitis(41.1%,131/319).The mortality rate among neonatal patients was 27.1%(76/280).In patients in the non-perinatal period,meningitis(70.1%,148/211)and sepsis(43.6%,92/211)were the main clinical manifestations,and the average patient age was 47.2 years.Among patients of known age,the highest prevalence was observed in the 40-64 year age group,which accounted for 44.9%(44/98).Sixty-one cases had no other underlying diseases before infection.Reported cases of listeriosis occurred in 27 provinces(municipalities,and autonomous region)in China,and Beijing reported the most cases,accounting for 23.7%(164/693).L.monocytogenes was sensitive to β-lactam drug treatment but showed differing degrees of drug resistance.Among 145 cases,12 were resistant to penicillin,and 16 were resistant to oxacillin.Listeriosis is a foodborne disease with a high mortality rate,particularly among neonates.With the continuing emergence of drug-resistant strains,standardizing and strengthening prevention and treatment measures for this disease as early as possible are essential.
