Rivaroxaban-caused abnormal liver function and blurred vision
10.3760/cma.j.issn.1008-5734.2013.04.016
- VernacularTitle:利伐沙班致肝功能异常及视物模糊
- Author:
Zong-ling XIA
1
;
Xue-cheng HAN
;
Ying ZOU
Author Information
1. 213000,苏州大学附属第三医院/常州市第一人民医院药剂科
- Publication Type:Journal Article
- Keywords:
Anticoagulants;
Alanine aminotransferase;
Glutamyl transpeptidase;
Rivaroxaban
- From:
Adverse Drug Reactions Journal
2013;15(4):224-226
- CountryChina
- Language:Chinese
-
Abstract:
A 75-year-old female patient received oral metoprolol (100 mg every morning and 75 mg every night) and rivaroxaban (20 mg every night) for hypertension and atrial fibrillation following the advice of doctor in hospital.One month later,liver function tests showed an alanine aminotransferase(ALT) value of 90 U/L and gamma-glutamyl transpeptidase(γ-GT) value of 133 U/L and the patient developed blurred vision.Rivaroxaban was stopped and,on the next day,her blurred vision disappeared.On day 3,the levels of ALT and γ-GT were 49 U/L and 73 U/L,respectively.On the second day after stopping rivaroxaban,oral warfarin 3 mg every night was given.The next day,the patient presented with hematuria and an emergency test showed an INR level of 0.98.The patient refused to continue using warfarin.Then she took reduced-dose rivaroxaban (10 mg every night and providing for herself) again and the liver function and ocular symptoms were monitored closely.Henceforth,the levels of ALT and γ-GT were normal basically and blurred vision did not recur.
