Research progress on improving cognitive impairment in schizophrenia based on N-methyl-D-aspartate receptor
10.3760/cma.j.cn113661-20231221-00253
- VernacularTitle:基于N-甲基-D-天冬氨酸受体改善精神分裂症认知功能损害的研究进展
- Author:
Xiangqin QIN
1
;
Wenpeng HOU
1
;
Chuanyue WANG
1
;
Fuchun ZHOU
1
Author Information
1. 首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室 北京脑重大疾病研究院精神分裂症研究所，北京 100088；首都医科大学人脑保护高精尖创新中心，北京 100069
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cognitive impairment;
N-methyl-D-aspartate receptor
- From:
Chinese Journal of Psychiatry
2024;57(12):852-858
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is one of the core symptoms of schizophrenia, and there is no recognized effective treatment for it. Current studies have found that treatment targeting the N-methyl-D-aspartate receptor (NMDAR) can improve cognitive function in patients with schizophrenia. This article reviewed the research progress of NMDAR-related modulators in improving cognitive impairment of schizophrenia, summarized the application of D-serine, glycine, D-cycloserine, memantine, etc., and discussed the current research deficiencies and future research directions .
