m6A modification and vascular remodeling
10.20039/j.cnki.1007-3949.2025.08.002
- VernacularTitle:m6A修饰与血管重构
- Author:
Xinlong LIU
1
;
Qian YU
1
;
Peng KONG
1
Author Information
1. 河北医科大学基础医学院生物化学与分子生物学教研室河北省血管生物学重点实验室神经与血管生物学教育部重点实验室,河北省石家庄市 050017
- Publication Type:Journal Article
- Keywords:
N6-methyladenosine modification;
vascular remodeling;
methyltransferase;
demethylase;
reading protein
- From:
Chinese Journal of Arteriosclerosis
2025;33(8):655-664
- CountryChina
- Language:Chinese
-
Abstract:
Vascular remodeling refers to a series of structural and functional abnormalities in the vascular wall,which is characterized by stenosis of the lumen,thickening of the vascular wall,reduction of vascular elasticity and compli-ance caused by changes in the microenvironment inside and outside the blood vessel,and ultimately the occurrence of car-diovascular events.Although the prevention,diagnosis and intervention of clinical cardiovascular diseases have improved,vascular dysfunction caused by vascular remodeling is still a huge problem and challenge that plagues clinical efficacy.N6-methyladenosine(m6A)modification is the most common and abundant post-transcriptional modification type in eukary-otic RNA.m6A methyltransferase,m6A demethylase and m6A reading protein are responsible for the occurrence,deletion and recognition of m6A modification,respectively.The m6A modification regulates the fate of important transcripts by participating in the splicing,degradation,translation,and subcellular translocation of RNA target molecules,thereby pla-ying a regulatory role in the maintenance of vascular physiological homeostasis and pathological remodeling.Studies have confirmed that m6 A modification-mediated vascular endothelial cell(EC)dysfunction,phenotypic transformation,abnormal proliferation,migration of medial vascular smooth muscle cell(VSMC),and aggregation and activation of monocytes/mac-rophages are involved in the occurrence and development of vascular remodeling diseases such as atherosclerosis and aneu-rysms.This article reviews the recent literatures on m6A modification in vascular remodeling,and discusses the effect of m6A methylation modification of important target molecules related to vascular remodeling on vascular cells function.Based on these,the intervention of m6A methylation may be a new target for clinical treatment and diagnosis in the future.
