Severe thrombocytopenia caused by sodium valproate
10.3760/cma.j.issn.1008-5734.2013.04.017
- VernacularTitle:丙戊酸钠致严重血小板减少
- Author:
Hui ZHAO
1
;
Ying ZHAO
;
Jian-cun ZHEN
;
Xing-shan ZHAO
Author Information
1. 100035,北京积水潭医院药剂科
- Publication Type:Journal Article
- Keywords:
Sodium valproate;
Thrombocytopenia
- From:
Adverse Drug Reactions Journal
2013;15(4):226-227
- CountryChina
- Language:Chinese
-
Abstract:
An 87-year-old woman with convulsions and bradycardia received a continuous Ⅳinfusion of sodium valproate 1200 mg once daily by a pump at a rate of 20 ml per hour.Her platelet count was 214 × 109/L before treatment.Eight days after treatment,her platelet count decreased to 63 × 109/L.Sodium valproate injection was withdrawn and her therapy was changed to sustained-release sodium valproate tablets 500 mg/d once daily.Five days later,the patient's platelet count decreased to 25 × 109/L.Sustained-release sodium valproate tablets were withdrawn.The patient received platelet transfusion 1 U and amino-polypeptide tablets 1000 mg three times a day.After eight days of symptomatic treatment,the patient's platelet count increased to 160 × 109/L.
