Progress in the role of reactive oxygen species induced by environmental factors on apolipoproteins in atherosclerosis
10.20039/j.cnki.1007-3949.2025.07.011
- VernacularTitle:环境因子诱导产生的活性氧对载脂蛋白的修饰作用在动脉粥样硬化中的研究进展
- Author:
Yiqiu LIU
1
;
Lei WANG
;
Yang YU
;
Jiguo ZHANG
Author Information
1. 山东第一医科大学(山东省医学科学院)药学院(药物研究所);山东第一医科大学(山东省医学科学院)实验动物学院(省实验动物中心),山东省济南市 250117
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
cardiovascular disease;
apolipoprotein;
environmental factors;
oxidative stress
- From:
Chinese Journal of Arteriosclerosis
2025;33(7):631-637
- CountryChina
- Language:Chinese
-
Abstract:
Environmental factors such as air pollutants,plastic micro-particles,ionizing radiation,and traffic noise promote the onset and progression of atherosclerotic cardiovascular disease(CVD)through mechanisms including inducing inflammatory responses,promoting oxidative stress,and accelerating lipid deposition.Notably,the modification of apoli-poprotein(Apo)by reactive oxygen species(ROS)accelerates this process.On one hand,ROS can oxidize key amino acid residues in Apo,altering its structure and thereby impairing its normal physiological function.On the other hand,ROS can induce lipid peroxidation of Apo,rendering the oxidized Apo more susceptible to recognition and uptake by macro-phages.This accelerates foam cell formation and drives the progression of atherosclerotic(As)plaques.This review summarizes recent research advances on the role of ROS-induced modification of Apo by environmental factors in atheroscle-rotic CVD.
