The role of the habenula and its neural circuitry in the pathological mechanism of depression and antidepressant treatment
10.3760/cma.j.cn113661-20231226-00263
- VernacularTitle:缰核及其神经环路在抑郁症病理机制与抗抑郁治疗中的作用
- Author:
Chengfeng CHEN
1
;
Wuyou BAO
;
Jie LI
;
Bin ZHANG
Author Information
1. 广州医科大学附属脑科医院精神科，广州510370
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Habenula;
DNeural circuit;
Antidepressant treatment
- From:
Chinese Journal of Psychiatry
2024;57(12):814-818
- CountryChina
- Language:Chinese
-
Abstract:
The habenula is a pair of tiny brain structures located in the diencephalon, serving as a hub connecting the forebrain and midbrain. It simultaneously regulates the release of dopamine and serotonin in the midbrain. Preclinical research has found that the habenula plays a significant role in physiological functions such as reward, aversion, and motivation, and may be involved in the pathogenesis of depression. Additionally, researches on antidepressant treatments such as ketamine and deep brain stimulation, have indicated that habenula is closely related to the efficacy of these therapies. This article systematically explains the role of the habenula′s volume, activation level, and its neural circuits in the pathological mechanism of depression and antidepressant treatments, while also exploring the prospects of novel therapies targeting the habenula.
