The role of mitochondrial homeostasis imbalance and dysfunction in the pathogenesis of depression
10.3760/cma.j.cn113661-20240605-00171
- VernacularTitle:线粒体稳态失衡和功能障碍在抑郁症发病机制中的作用
- Author:
Yinping XIE
1
;
Lujia SI
;
Hailong GE
;
Chen LI
;
Junjie HUANG
;
Leimin WANG
;
Ling XIAO
;
Gaohua WANG
Author Information
1. 武汉大学人民医院湖北省神经精神病研究所，武汉 430060
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Mitochondrial homeostasis;
Mitochondrial dysfunction;
ATP synthesis;
Oxidative stress;
Inflammation
- From:
Chinese Journal of Psychiatry
2024;57(12):808-813
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder is a common mental disorder with high rate of disability and suicide rate, but its pathogenesis remains unclear. Numerous studies indicate that energy metabolism is impaired in patients with depression, with the changes in the expression of critical genes that regulate mitochondrial homeostasis (mitochondrial biogenesis, fusion and fission, and mitophagy). Mitochondrial dysfunction, leading to reduced ATP production, oxidative stress, and inflammation, plays a significant role in the onset and development of depression, but the mechanism is still uncertain, and conflicting research findings exist. This paper reviews the intrinsic connections and potential mechanism between mitochondrial homeostasis imbalance, dysfunction, and depression, from two aspects: mitochondrial imbalance and dysfunction. It also discusses the limitations of current research, providing insight into understanding the pathogenesis of depression and developing novel mitochondrial-targeted therapeutic strategies.
