Antimicrobial susceptibility and phylogenetic analysis of 31 Nocardia isolates
10.3969/j.issn.1002-2694.2025.00.106
- VernacularTitle:31株诺卡菌分离株的药物敏感性与进化分析
- Author:
Xin-yan DONG
1
;
Li-heng ZHENG
;
Wei-li GAO
;
Hong ZHANG
;
Fei LU
;
Yu-mei GUO
Author Information
1. 河北省疑难病原研究重点实验室,石家庄市疾病预防控制中心,石家庄 050011
- Publication Type:Journal Article
- Keywords:
Nocardia;
antibiotic resistance genes;
Nocardia farcinica
- From:
Chinese Journal of Zoonoses
2025;41(6):636-640
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the disease characteristics and clinical traits of Nocardia infection,and analyzed the antibiotic resistance phenotypes,antibiotic resistance genes,and evolutionary characteristics of the strains,to provide a basis for Nocardia diag-nosis and treatment.A total of 31 Nocardia strains from a hospital in Hebei Province were collected from 2020 to 2023.The strains were identified through mass spectrometry and whole genome sequencing.Antibiotic susceptibility testing was conducted with the broth macrodilution method,and whole genome sequencing data were used to predict antibiotic resistance genes and comprehensively ana-lyze antibiotic resistance phenotypes.The 31 strains of Nocardia comprised 21 strains of Nocardia farcinica,3 strains of Nocardia ter-penica,three strains of Nocardia brasiliensis,two strains of Nocardia cyriacigeorgica,and two strains of Nocardia nova.The ceftriaxone susceptibility of 21 Nocardia farcinica strains was 85.7%,and all 31 strains were susceptible to imipenem,except for three strains of Nocardia brasiliensis.Rifampicin,aminoglycoside,and β-lactam resistance genes were found in Nocardia farcinica.Pathogenic tests should be carried out in a timely manner for suspected Nocardia infections.In clinical treatment of Nocardia infection,infected strains should be confirmed,and antibiotics should be used rationally according to the antibiotic susceptibility test results.
