A case-control study on the association of indoleamine 2, 3-dioxygenase gene polymorphism with schizophrenia in Chinese Han population
10.3760/cma.j.cn113661-20231026-00160
- VernacularTitle:中国汉族人群吲哚胺2，3-双加氧酶基因多态性与精神分裂症病例对照关联研究
- Author:
Song LIU
1
;
Zhaonian CHEN
;
Xiujuan WANG
;
Xiaoge GUO
;
Han SHI
;
Luwen ZHANG
;
Xi SU
;
Luxian LYU
;
Wenqiang LI
;
Yongfeng YANG
Author Information
1. 新乡医学院第二附属医院 河南省精神病医院精神科，新乡453002
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Indoleamine 2,3-dioxygenase;
Polymorphism, single nucleotide;
Haplotypes;
Case-control studies
- From:
Chinese Journal of Psychiatry
2024;57(11):748-754
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the association between single nucleotide polymorphisms (SNP) of indoleamine 2,3-dioxygenase( IDO) genes and schizophrenia (SZ) in a Chinese Han population. Methods:Using a case-control study method, 3 700 in-patients with SZ were recruited from January 2010 to December 2021 at the Second Affiliated Hospital of Xinxiang Medical University, and 8 580 healthy controls were recruited from surrounding communities in Xinxiang City. The patient group and control group were matched in gender and age. After collecting peripheral blood from all subjects and extracting genomic DNA, the sample DNA was genotyped using methods such as gene chips and amplification refractory mutation system. The association analysis between IDO gene SNPs and SZ was conducted using the online analysis tool SHEsis. The differences in IDO gene SNP genotype and allele frequency between the two groups were compared using chi-square test. Linkage disequilibrium analysis, haplotype analysis, and Hardy Weinberg equilibrium test were performed using Haploview v4.2 software. A multifactor dimensionality reduction software was used to evaluate the interaction between SNPs and SNP frequencies. Results:In the four SNP loci of IDO gene, there was a significant difference in genotype and allele frequency between the SZ patient and the health control at rs9657182 locus (χ 2=11.81, P=0.003;χ 2=5.54, P=0.019). After Bonferroni correction, the genotype difference at rs9657182 locus still showed statistical significance ( P=0.011). There were no statistically significant differences in genotype and allele frequency among the three SNP locis (rs7820268, rs4503083, and rs10109853). Further stratified by gender, there was no significant difference in genotype frequency between the two groups at the rs9657182. Haplotype analysis revealed that the haplotype of CC and TC (rs9657182 and rs7820268) were significantly different between the two groups (χ 2=3.93,4.78, P=0.048, 0.029). Conclusion:The rs9657182 locus of IDO gene may be a susceptible locus for SZ. The haplotype of CC and TC may be associated with the onset of SZ.
