Recent advances in the pathogenesis and preventive strategies of abdominal aortic an-eurysm
10.20039/j.cnki.1007-3949.2025.07.004
- VernacularTitle:腹主动脉瘤的发病机制及防治策略研究进展
- Author:
Qingqing LEI
1
;
Ziwen SHEN
;
Mengxian SUN
;
Tingting ZHANG
Author Information
1. 中山大学附属第八医院心血管内科,广东省 深圳市 518033
- Publication Type:Journal Article
- Keywords:
abdominal aortic aneurysm;
vascular smooth muscle cell;
phenotypic switching;
inflammation;
metabolic reprogramming
- From:
Chinese Journal of Arteriosclerosis
2025;33(7):579-586
- CountryChina
- Language:Chinese
-
Abstract:
Abdominal aortic aneurysm(AAA)is characterized by a localized and irreversible enlargement of the abdominal aorta,which poses a significant risk to life in the event of rupture.Currently,the primary treatment for AAA is surgical intervention,as there are no effective pharmacological therapies available to prevent or slow postoperative vascular dilation.Therefore,understanding the detailed pathogenesis of AAA and identifying effective prevention and treatment strategies is essential.This review begins by examining the pathological and molecular mechanisms involved in AAA,fo-cusing on key research areas such as the phenotypic switching of vascular smooth muscle cells,inflammation and metabolic reprogramming.Based on a large of animal and clinical studies,this review then explores therapeutic strategies and prom-ising drugs for AAA,including mesenchymal stem cell therapy,nanomaterial applications,and immunomodulatory inter-ventions.The review aims to provide researchers with new ideas and directions for the prevention and treatment of AAA.
