Brain-specific angiogenesis inhibitor 1-associated protein 2 gene associates with executive functions in Han Chinese children with attention deficit/hyperactivity disorder
10.3760/cma.j.cn113661-20231027-00163
- VernacularTitle:脑特异性血管发生抑制剂1相关蛋白2基因与中国汉族注意缺陷多动障碍儿童执行功能的关联分析
- Author:
Haimei LI
1
;
Pei LIU
;
Ningning LIU
;
Lu LIU
;
Yufeng WANG
;
Qiujin QIAN
Author Information
1. 北京大学第六医院 北京大学精神卫生研究所 国家卫生健康委员会精神卫生学重点实验室（北京大学）国家精神心理疾病临床医学研究中心（北京大学第六医院），北京 100191
- Publication Type:Journal Article
- Keywords:
Attention deficit disorder with hyperactivity;
Brain-specific angiogenesis inhibitor 1-associated protein 2;
Executive function;
Association analysis
- From:
Chinese Journal of Psychiatry
2024;57(11):721-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the associations between several single nucleotide polymorphisms (SNPs) at BAIAP2 with executive functions in patients with attention deficit/hyperactivity disorder (ADHD) and in healthy control subjects. To investigate if these associations are sex-specific and/or subtype-specific. Methods:A total of 929 Han Chinese youths with DSM-Ⅳ ADHD were recruited from the outpatient department of Peking University Sixth Hospital from May 2005 to January 2011, and 161 unaffected controls were recruited from the primary and secondary schools in Beijing from January 2005 to January 2010. All subjects were rated for the clinical information and executive functions based on laboratory examinations, such as inhibition, working memory, and set shifting. Four SNPs of BAIAP2 were chosen and genotyped using TaqMan TM real-time PCR assays. Analysis of covariance (ANCOVA) were conducted, with gender, age and IQ as covariates, to compare executive functions between children with ADHD and normal controls, and to explore the association of BAIAP2 SNPs with executive functions of ADHD subjects (total samples and sex/subtype stratified samples) and unaffected controls. Results:Compared to unaffected controls, children with ADHD performed significantly worse in inhibition ( F=11.64, 26.50, P≤0.001) and set shifting ( F=25.68, P<0.001). In unaffected controls, there was no correlation between any BAIAP2 SNPs and executive functions. In ADHD cases, rs4969239 was significantly associated with set shifting times, with G allele carriers used longer time than others and had a worse set shifting function (B=-17.55, F=7.13, P=0.008), and rs9901648 was significantly associated with color interference time, with AA genotype carriers used longer time than others and had a worse inhibition function (B=1.82, F=8.84, P=0.003). In further analysis, the association between rs9901648 and color interference only existed in male participants with ADHD ( F=11.33, P=0.001). Conclusions:BAIAP2 gene possibly contributes to the set shifting and inhibition impairment in children with ADHD, but not in unaffected controls. In addition, the association between BAIAP2 gene and inhibition mainly exists in male children with ADHD.
