Progress in the treatment of endothelial dysfunction in atherosclerosis
10.20039/j.cnki.1007-3949.2025.08.011
- VernacularTitle:动脉粥样硬化中抗内皮功能障碍的治疗进展
- Author:
Xinyu ZHANG
1
;
Ziyue XIE
;
Zi'an WANG
;
Yu LI
;
Ruigong ZHU
Author Information
1. 南京中医药大学医学院,江苏省南京市 210023
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
endothelial dysfunction;
pharmacotherapy
- From:
Chinese Journal of Arteriosclerosis
2025;33(8):721-728
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic vascular wall disease.The clinical manifestations are abnormal lipid depo-sition,fibrous hyperplasia,calcium deposition,etc.under the intima of the affected artery lesions.Its initial link is re-lated to endothelial cell dysfunction,which can be triggered and aggravated by different risk factors of atherosclerosis,in-cluding oxidative stress,hemodynamic abnormalities,endothelial cell senescence and inflammation,etc.Exploring the mechanism of endothelial cell dysfunction is conducive to the discovery of potential treatments for atherosclerosis.This ar-ticle summarizes the mechanism and research progress of drug therapy for endothelial cell dysfunction in atherosclerosis.
