Research progress in mechanism of tamoxifen-induced fatty liver
10.3760/cma.j.issn.1008-5734.2016.04.010
- VernacularTitle:他莫昔芬致脂肪肝机制研究进展
- Author:
Nana WANG
1
;
Guiqin ZHOU
Author Information
1. 北京中医药大学
- Publication Type:Journal Article
- Keywords:
Tamoxifen;
Fatty liver
- From:
Adverse Drug Reactions Journal
2016;18(4):290-292
- CountryChina
- Language:Chinese
-
Abstract:
Tamoxifen is widely used in the treatment of patients with estrogen receptor positive breast cancer.Tamoxifen can lead to fatty liver.Risk factors of tamoxifen induced fatty liver were obesity,hyperlipidemia,and hyperglycemia.The mechanism of tamoxifen induced fatty liver includes drugs estrogen antagonism,influence on fatty acid metabolism enzyme expression and activity,promoting fatty acid synthesis,and influencing lipid metabolism related nuclear receptors.The above factors interfering with fatty acid metabolism cause fat accumulation in the liver.Obeticholic acid can improve the prognosis of patients with fatty liver induced by tamoxifen.
