Research progress on common pathological factors of cognitive and depressive symptoms in Alzheimer′s disease
10.3760/cma.j.cn113661-20231222-00258
- VernacularTitle:阿尔茨海默病认知症状和抑郁症状共有病理因素的研究进展
- Author:
Ling HUANG
1
;
Yuanzhi ZHAO
;
Zheng ZHAO
;
Xiaohong WU
;
Xiangping WU
;
Wei CUI
Author Information
1. 宁波大学附属康宁医院精神科 宁波大学附属精神卫生中心，宁波315201
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
Depression;
Epidemiology;
Pathological factors;
Neurotransmitters
- From:
Chinese Journal of Psychiatry
2024;57(10):692-697
- CountryChina
- Language:Chinese
-
Abstract:
Patients with Alzheimer′s disease (AD) often exhibit both cognitive and depressive symptoms, suggesting a strong connection between the two, potentially indicating shared pathological factors. This article reviews the common pathological factors underlying cognitive and depressive symptoms in AD, focusing on aspects such as genetic factors, neurodegeneration, hypothalamic pituitary adrenal axis (HPA) dysfunction, neurotrophic factor deficiency, enhanced neuroinflammation, gut microbiota imbalance, and neurotransmitter systems imbalance. Further research on these common pathological factors is of great significance for future AD treatment.
