Research progress on drug-induced gynecomastia
10.3760/cma.j.issn.1008-5734.2015.05.008
- VernacularTitle:药源性男性乳腺发育症研究进展
- Author:
Ailing ZHANG
1
;
Guijun QIN
;
Haiyang MENG
;
Yanxia LIU
;
Xiaojian ZHANG
Author Information
1. 450052,郑州大学第一附属医院药学部
- Publication Type:Journal Article
- Keywords:
Drug toxicity;
Gynecomastia;
Gonadal hormones
- From:
Adverse Drug Reactions Journal
2015;17(5):357-360
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced gynecomastia with the benign enlargement of male breast glandular tissue was reported to cause an imbalance between estrogen and androgen action then lead to an increased estrogen to androgen ratio by drugs.Drugs are estimated to cause about 10％ ～ 25％ of all cases of gynecomastia.Some commonly used drugs, such as spironolactone, ketoconazole, imatinib, bicalutamide, finasteride,cimetidine can cause gynecomastia.Clinical manifestations of drug-induced gynecomastia cause breast pain,tenderness or galactorrhea.Estradiol and estriol increased, while luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone decreased in the laboratory tests.In the patients with druginduced gynecomastia the causative medications should be withdrawn;if gynecomastia persists, the patients can be treated with tamoxifen.Surgery can be performed if treatment with tamoxifen was not effective or the clinical manifestations persist for one year.
