Association between the presence of peritumoral retraction clefts and clinicopatho-logical features and prognosis in esophageal squamous cell carcinoma
10.13315/j.cnki.cjcep.2025.07.008
- VernacularTitle:食管鳞状细胞癌中肿瘤周围退缩裂隙的出现与临床病理特征及预后的关系
- Author:
Ning ZHU
1
;
Zhiwen LI
;
Yuan FANG
;
Li LI
Author Information
1. 南京市第一医院/南京医科大学附属南京医院病理科,南京 210006
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
squamous cell carcinoma;
peritumoral retraction clefts;
lymphatic invasion;
prog-nosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(7):892-896,903
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological significance of peritumoral retraction clefts(PRC)in esophageal squamous cell cancer(ESCC)and its correlation with prognosis.Methods 266 cases of esophageal squa-mous cell carcinoma were collected.Excluding the cases due to incomplete clinical data,cracks caused by the produc-tion process,and receiving preoperative adjuvant treatment,248 cases were finally counted.PRC was determined by the proportion of retraction clefts in the tumor volume of 10％.A retrospective analysis was conducted to explore the re-lationship between PRC and the clinicopathological features as well as prognosis of ESCC.Results Among 248 ESCC patients,114 cases had PRC,while 134 cases did not.Correlation analysis showed that PRC was closely related to his-tological grade,lymphatic invasion,lymph node metastasis,depth of tumor invasion and TNM stage of ESCC,and ES-CC patients with PRC were more likely to have lymphatic invasion and lymph node metastasis(P＜0.05).In patients without lymphatic invasion,the probability of nodal metastasis in patients with PRC was higher than those without PRC,and the difference was statistically significant(P＜0.001).Kaplan-Meier survival analysis showed that 5-year overall survival(P=0.001)and progression-free survival(P=0.002)in ESCC patients with PRC were significantly lower than those without PRC.Conclusion ESCC patients with PRC are more likely to have local invasiveness,lymphatic invasion and nodal metastasis,may predict the poor prognosis of ESCC patients.Patients with nodal metastasis are more common with PRC.
