Cortical thickness abnormalities in drug-naive first-episode adult depression: a Meta-analysis
10.3760/cma.j.cn113661-20230916-00068
- VernacularTitle:首次发病未服药成年抑郁症患者大脑皮质厚度变化的Meta分析
- Author:
Liangliang PING
1
;
Shan SUN
;
Cong ZHOU
;
Mengxin HE
;
Jianyu QUE
;
Qi ZHENG
;
Zonglin SHEN
;
Xiufeng XU
;
Yuqi CHENG
Author Information
1. 昆明医科大学第一附属医院精神科，昆明650032
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
First-episode;
Cortical thickness;
Meta-analysis
- From:
Chinese Journal of Psychiatry
2024;57(8):512-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This meta-analysis aims to explore the most consistent changes in cortical thickness in drug-naive first-episode patients with major depressive disorder (DF-MDD).Methods:Systematic and comprehensive searches were conducted to acquire relevant literature from the PubMed and Web of Science databases for the studies published from inception to July 23, 2023, by using the keywords ("depression" OR "depressive disorder" OR "unipolar depression") AND ("cortical thickness"OR"thickness"). The SDM (signed differential mapping) software was used to perform whole-brain voxel-wise meta-analysis, heterogeneity test, and assess publication bias. Meta-regression analysis was employed to examine the impact of disease severity on cortical thickness in depression, and heterogeneity was tested, along with an assessment of publication bias.Results:Eight studies were ultimately included, encompassing 417 DF-MDD patients and 409 healthy controls. Compared to the healthy control group, DF-MDD patients exhibited significantly decreased cortical thickness in multiple brain regions, including the supplementary motor area ( Z=-2.471, P<0.000 5) and the rolandic operculum ( Z=-2.190, P<0.000 5). Further regression analysis found that the disease severity was positively correlated with the cortical thickness in the supplementary motor area ( Z=2.265, P<0.000 5) and the rolandic operculum ( Z=1.56, P<0.000 5). Additionally, the average depressive duration was positively correlated with cortical thickness in the right opercular part of the inferior frontal gyrus ( Z=1.922, P<0.000 5), and negatively correlated with changes in the right midcingulate cortex ( Z=-3.035, P<0.000 5) in DF-MDD. Conclusion:DF-MDD patients exhibit reduced cortical thickness in the supplementary motor area and the operculum area during the early stages of the disease. And the observed pattern of cortical alterations is associated with both the severity and duration of the disease.
