Dual value of high expression of HDGF in prognosis assessment and im-munotherapy of hepatocellular carcinoma
10.3969/j.issn.1009-9905.2025.07.004
- VernacularTitle:HDGF高表达在肝细胞癌预后评估及免疫治疗中的双重价值
- Author:
Ting-ting WANG
1
;
Jian-lei WANG
;
Hong-mei DING
;
Ze-yang LIU
Author Information
1. 山东大学齐鲁医院 器官移植科(山东 济南 250012)
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Hepatoma-derived growth factor;
Tumor-immune microenvironment;
Prog-nosis;
Demethylation
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(7):522-529
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The current study was designed to elucidate the expression pattern,prognosis value,im-mune characteristics and potential molecular mechanisms of HDGF in HCC.Methods:Clinical and gene expression data of the TCGA-LIHC cohort were collected.The Kaplan-Meier method,time-dependent receiver operating charac-teristic(ROC)curves and Cox regression analysis were used to analyze the prognostic value of HDGF.The expression level difference of HDGF was analyzed using the R package DESeq2.Gene ontology,KEGG and GSEA analyses were used to determine the biological function of HDGF in HCC development.The SsGSEA method were used to analyze the immune infiltrates of HCC.Human methylation 450 data and level 3 HTSeq-FPKM data from TCGA-LIHC were used to analyze the effects of DNA methylation level on HDGF expression.Results:Our results indicated that HDGF was over-expressed in HCC and correlated with historical grade and AFP levels(P<0.001).HDGF expression level is an indepen-dent risk factor for overall survival in patients with HCC(P=0.008).The functional and immune analysis indicated that HDGF is closely related to tumor-immune microenvironment and immune infiltration,especially Cytotoxic cells,pDC and Th2 cells(P<0.001).In addition,high HDGF expression in HCC was associated with demethylation of its promoter region(P<0.05).Conclusion:Our results demonstrated that HDGF independently predicts unfavorable prognosis and regu-lates the immune microenvironment of HCC,suggesting HDGF as a potential immunotherapeutic target for HCC.
