Evaluation of ATP bioluminescence technology for cleaning and disinfection of flexible endoscopes: a meta-analysis
10.3760/cma.j.cn321463-20240110-00018
- VernacularTitle:ATP生物荧光测定法检测软式内镜清洗消毒效果的meta分析
- Author:
Can ZHAO
1
;
Longsong LI
1
;
Ke HAN
1
;
Yawei BI
1
;
Enqiang LINGHU
1
;
Ningli CHAI
1
Author Information
1. 中国人民解放军总医院第一医学中心消化内科医学部，北京100853
- Publication Type:Journal Article
- Keywords:
Flexible endoscope;
Cleaning and disinfection;
ATP bioluminescence technology;
Microbiological detection;
Meta analysis
- From:
Chinese Journal of Digestive Endoscopy
2025;42(8):639-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the efficacy of ATP bioluminescence technology versus traditional microbiology detection method in assessing flexible endoscope cleaning and disinfection.Methods:Eight Chinese and English databases, including PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, VIP Chinese Medical Journal Database and China Biology Medicine disc, were searched from inception to October 1, 2023. Comparative studies on evaluating post-reprocessing endoscope quality using both methods were included. Positive sample numbers and positive rates were taken as the main effect indicators, and the fixed effect model was used to conduct a meta-analysis of the included literature.Results:A total of 14 Chinese and English articles were included, involving 4 569 samples (gastroscopes, colonoscopes, duodenoscopes and fiberbronchoscopes). The pooled analysis demonstrated low heterogeneity across studies ( I2=23%), with a combined odds ratio ( OR) of 1.57 (95% CI: 1.27-1.94). It indicated a statistically significant difference in positive detection rates between the two methods ( P<0.001). However, funnel plot analysis suggested potential publication bias. Conclusion:ATP bioluminescence correlates with microbiological methods for monitoring endoscope reprocessing. While ATP offers rapid assessment advantages, its consistently higher positive rates preclude replacement of conventional microbiological verification for terminal disinfection.
