Abnormal liver function due to intravenous infusion of moxifloxacin

VernacularTitle:静脉滴注莫西沙星致肝功能异常
Author: Rui YANG ¹ ; Xin HUANG ¹ ; Yi HAN ¹ ; Le-qun SU ¹ ; Hong-jian LI ¹
Author Information

1. 山东省千佛山医院药学部,济南,250014
Publication Type:Journal Article
Keywords: Moxifloxacin; Drug-induced liver injury
From: Adverse Drug Reactions Journal 2013;15(2):105-106
CountryChina
Language:Chinese
Abstract: A 64-year-old man received an Ⅳ infusion of moxifloxacin 0.4 g once daily with concomitant use of oral Feilike capsules (肺力咳胶囊)and oral cetirizine for pulmonary infection.On day 2,biochemical tests showed an alanine aminotransferase (ALT) level of 49 U/L and an aspartate aminotransferase (AST) level of 30 U/L.On day 5,the values of ALT and AST rose to 166 U/L and 53 U/L,respectively.On day 9,moxifloxacin was withdrawn and changed to levofloxacin 0.5 g once daily orally.Meanwhile,liver-protective treatment was given and Feilike capsules and cetirizine were continued at original dosage.On day 10,the values of ALT and AST were respectively 111 U/L and 28 U/L,and on day 13,the value of ALT was 77 U/L and the value of AST was 23 U/L.Two months later,hepatic function returned to normal (an ALT level of 28 U/L and an AST level of 21 U/L).