The T Cell Homing Mechanism and Its Translational Strategy in Immunotherapy for Solid Tumors
10.13865/j.cnki.cjbmb.2025.05.1131
- VernacularTitle:T细胞归巢机制及其在实体瘤免疫治疗中的转化策略
- Author:
Yan XIE
1
;
Yu-Ting HE
1
;
Yang-Kun SHEN
1
Author Information
1. 福建师范大学生命科学学院,福建师范大学南方生物医学研究中心,福建省天然免疫生物学重点实验室,福州 350117
- Publication Type:Journal Article
- Keywords:
adoptive T cell transfer therapy;
T cell homing;
chemokines;
tumor treatment
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):997-1006
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,adoptive T cell immunotherapy has become a research hotspot in cancer treat-ment,in which the directional homing of T cells to tumor tissues is the core of the anti-tumor immune re-sponse,which is closely related to good clinical treatment outcomes.However,the infiltration of T cells into solid tumors remains challenging due to the complex tumor microenvironment,tumor vasculature bar-riers,and loss of chemotaxis signals.This review systematically outlines the migration pathways of T cell homing,including blood homing after intravenous infusion,transvascular endothelial migration,and its infiltration into targeted solid tumor tissues.On this basis,we also explore the regulatory mechanism of T cell homing,especially the synergistic relationship between the chemokine-receptor axis,and the effects of tumor vascular abnormalities,tumor microenvironment(TME)-shaped infiltration barriers,and tumor stromal barriers on T cell homing.In response to the above obstacles,three main strategies to enhance the homing efficiency of T cells are reviewed.First,chemokine receptors(e.g.,CXCR2,CXCR6)are modified to match tumor chemotaxis signals,or immune checkpoint molecules(PD-1,LAG-3,SHP-1)are knocked out to reverse T cell exhaustion by CRISPR gene editing or lentiviral transduction technolo-gy.Second,targeting the VEGF/VEGFR axis combined with ATCT can promote vascular normalization and improve T cell infiltration.Third,the combination of local therapy(radiotherapy,oncolytic virus)or systemic drugs(chemotherapy,immune checkpoint inhibitors,etc.)can improve the homing of T cells by remodeling tumor TME.These strategies will provide a theoretical basis and research direction for a-doptive T cell immunotherapy in the treatment of solid tumors.
