Pathophysiologic Role of Endoplasmic Reticulum-Mitochondrial Interaction in Regulating Calcium Transport
10.13865/j.cnki.cjbmb.2025.03.1470
- VernacularTitle:内质网-线粒体交互调节钙转运的病理生理作用
- Author:
Hong ZHANG
1
;
Zi-Chen WANG
1
;
Zi-Gang ZHAO
1
Author Information
1. 河北北方学院微循环研究所,河北 张家口 075000;河北北方学院基础医学院,河北 张家口 075000
- Publication Type:Journal Article
- Keywords:
mitochondria-associated endoplasmic reticulum membrane(MAM);
calcium transport;
cal-cium overload
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):987-996
- CountryChina
- Language:Chinese
-
Abstract:
The structure and function of mitochondria and endoplasmic reticulum(ER)are important for maintaining cellular homeostasis.It has been found that the interaction between mitochondria and ER is involved in the occurrence and development of a variety of diseases.The mitochondria-associated ER membrane(MAM)is a membrane contact site between the ER and mitochondria,and is an important communication center between organelles in eukaryotic cell.Calcium channels on the ER side and the mitochondrial side are crucial in the calcium transport process in MAM.The interaction between ER and mitochondria controls mitochondrial biological function and cell survival through calcium transport regula-tion,and are involved in the occurrence and development of various pathologic process.On the one hand,MAM regulates calcium transport,which is involved in the modulation of various cellular survival and death processes.It plays a profound regulatory role in the damage of tumor cells,neuronal cells,car-diomyocytes,endothelial cells and nucleus pulposus cells through different key molecules within MAM.On the other hand,the regulation of MAM in calcium transport is crucial in the development of mitochon-drial dysfunction in Hepa 1-6 cells,the synthesis and secretion of pancreatic β-cells and amyotrophic lat-eral sclerosis.In addition,MAM also affects cellular transcription processes by regulating calcium trans-port,thereby exerting significant regulatory effects on angiogenesis and breast cancer.This paper reviews the structural features and pathophysiologic role of calcium transport regulation of MAM,and expects to provide new horizons for prevention and treatment of related diseases targeting MAM.
