The Vesicle Transport Functions of the Conserved Oligomeric Golgi Complex
10.13865/j.cnki.cjbmb.2025.05.1006
- VernacularTitle:保守寡聚高尔基体复合物的囊泡运输功能
- Author:
Jia-Ning SONG
1
;
Hao-Lin ZHANG
1
;
Juan WANG
1
Author Information
1. 北京工业大学化学与生命科学学院生物学系,北京 100124
- Publication Type:Journal Article
- Keywords:
conserved oligomeric Golgi(COG);
vesicle trafficking;
autophagy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(7):947-955
- CountryChina
- Language:Chinese
-
Abstract:
As a tethering complex localized on the Golgi membrane,the conserved oligomeric Golgi(COG)complex is divided into lobes A(COG1-4)and B(COG5-8)and forms a complete hetero-oc-tamer structure through the dynamic linkage of COG1 to COG8.Through coordinated interactions with Rab GTPases,SNARE proteins,and Golgi-associated coiled-coil tethers(CCTs),the COG complex par-ticipates in coatomer complex Ⅰ(COP Ⅰ)-mediated retrograde transport,coatomer complex Ⅱ(COP Ⅱ)-mediated anterograde transport,and various autophagic processes.The functional mechanism of the COG complex includes two models.First,the"disassembly and assembly model",in which lobe A anchors the Golgi membrane,while lobe B binds to the vesicle membrane,and both lobes assemble into the com-plete COG complex to narrow the distance between vesicle and target membranes.Second,the"docking station assembly model",in which COG complexes cooperate with SNARE,Rab and other molecules to form a stable docking platform,to enhance the stability of SNARE complexes and promote membrane fu-sion efficiency.Additionally,the COG complex is involved in macroautophagy,the vacuole targeting(Cvt)pathway,and pexophagy.In this review,we introduce the regulatory mechanism of the COG com-plex in several species,and summarize the factors that have synergetic effects with the COG complex in vesicle transport.
